Sherm Feller decided he wanted to work in radio, and he first worked in Manchester NH at WMUR. His first radio job in greater Boston was in Lowell, where he was hired by WLLH in late 1941 (Variety, December 31, 1941). He was on the air in Boston, at station WEEI, where he became well-known as host of "Club Midnight," and also wrote a music column for the Boston American newspaper ("Vox Jox," 20). Some sources say he was the first Boston announcer to do a call-in talk show ("Sherm Feller Dies" 4), although back then, it was not possible to put callers on the air. Announcers would repeat or paraphrase what the caller was saying. As was the custom in that era, announcers frequently left one station to work for another.

Feller served as the Fenway Park public address announcer for 26 years beginning in 1967 and continuing till just before his death in early 1994 (Long, 26). He was known throughout baseball for his distinct voice which was described as being slow with a gravely, measured cadence. Sherm attributed his unique sound to the fact that he spoke without his dentures while calling a game. He was also known for keeping his announcements simple, often giving the batter's uniform number, full name, his position, and his last name when the batter stepped up to the plate, such as "Number 26, Wade Boggs. Third base, Boggs."  He was also known to generations of Red Sox fans for beginning each Red Sox home game with, "Ladies and gentlemen, boys and girls, welcome to Fenway Park." Today, games broadcast on NESN begin with a soundclip of Sherm Feller making this announcement.