Bob Murphy was born on September 19, 1924. He attended the University of Tulsa and Colorado College.  His first sportscasting assignment was the coverage of the Muskogee Reds if the Western Association in 1947.  After a year describing the doings of the Tulsa Oilers, he moved to Oklahoma City where, for five years, he broadcasted the games of that city's Texas League team, along with the football games of Oklahoma and the basketball games of Oklahoma A&M.

In 1954, he joined Curt Gowdy as the play-by-play announcer for the Red Sox, a spot he maintained until 1959.  In 1960, he moved to the Baltimore Orioles for two seasons, replacing Ernie Harwell.

Bob's call of Roger Maris' record-tying 60th home run of the 1961 season became an audition tape that landed him a job with the expansion New York Mets in 1962.  He went to broadcast the New York Mets, from their inception in 1962 until his retirement in 2003.  From the Mets' first game in 1962 through the post-Tom Seaver days of 1978, on radio and television, the Mets games were announced by the trio of Lindsey NelsonRalph Kiner and Bob. Nelson left after the 1978 season and was replaced by Steve Albert, who broadcast the Mets for three seasons.  In addition to his baseball work, Bob was an announcer for the New York Titans (renamed the New York Jets) of the American Football League in 1962-63

Because he was so well known for his sunny outlook, he opened games saying "The sun is shining the sky is blue, its a beautiful day for baseball", an unprecedented display of crankiness on his part received much attention. 

In his later years, Bob Murphy (a smoker) began having trouble calling games due to persistent throat inflammation. After the  season, he left the broadcast booth, retired and passed away due to lung cancer on August 3, 2004, in West Palm Beach, Florida.