Charley Leo showed up to the training camp after being signed by a free agent in 1960 by the Boston Patriots. He was kept on the team by coach Lou Saban and started as a guard on the offensive line. In his rookie season as a Patriot, he was named second all-pro. Always striving to do better after being drafted for a short career in the United States Army, he was named first all-pro in 1961. In 1962, he played four games before he severely tore his hamstring in a non-football related accident. Unable to get the injury to heal so he could return to his prior playing level, he did not return to the Patriots offensive line and was let go by the team.