Ike Frankian was born in Worcester, Mass on April 3, 1907. His family moved to California and he graduated from Duniba High School. He went on to become an All-American receiver for St. Mary's College and in 1927 and 1928.

In 1933 he signed with the Boston Redskins and played in 12 games, and caught six passes for 75 yards, scoring one touchdown. In 1934 and 1935 he played with the New York Giants and then for the Los Angeles Bulldogs in the Pacific Coast Professional League for three years.

After his playing days, Ike coached at St. Mary's for three years and then coached the Los Angeles Bulldogs from 1938 thru 1948. He became the head of the physical education department at Dos Palos Union High School in 1941.

Ike Frankian had a heart attack and passed away at his home in Dos Palos, California on April 14, 1963, at age 56.