Luke Urban was the Boston College footbal team's captain and a consensus first-team All-American. Though known mainly for playing football, Urban was also active on the baseball, basketball and hockey teams.

He is one of only a handful of Boston College athletes to earn varsity letters in four different sports. Coach Cavanaugh characterized Urban as the "most modest man I ever coached" and a psychology professor added that he was the "most unselfish man in the college."

Urban served as Boston College's head basketball coach during his sophomore, junior and senior seasons.

Following his graduation, Urban was offered the position of head football coach at Creighton University, but turned down the offer in order to play professional football.

Urban played end for the Buffalo All-Americans from 1921 to 1924. He was named to the All-APFA Team in 1921, George Halas' All-NFL Team in 1922, and the Collyers Eye Magazine and Canton Daily News All-NFL Team in 1923. From 1921 to 1930, he was the head basketball and football coach at Canisius College. His football teams had a record of 46–27–7 record, with of his eight clubs having a record of .500 or better.

Urban signed with the New York Yankees and played for their minor league teams in Buffalo and Columbus. He made the Major Leagues in 1927 with the Boston Braves. He appeared in 35 games for the Braves that seasoN. On June 22, 1928, he was traded with Jimmy Cooney and Johnny Werts for Bonnie Hollingsworth. He played for Buffalo from 1928 to 1930 and the Springfield Ponies in 1931, and the Hartford Senators from 1931 to 1932.

He was the head basketball coach at Durfee High School in Fall River, Massachusetts from 1940 to 1960. He had a 247–91 record with the Hilltoppers and won two New England championships.