Mike Lowell overcame cancer and went on to become a World Series champion, once with the Florida Marlins and a second time with the Red Sox.

Lowell was making decent money in Florida and the Marlins, who were unloading payroll after their 2003 World Series win. They included him as a throw-in with Josh Beckett, in a trade with the Red Sox at the end of 2005. The Sox were happy because they knew Mike's glove would be an asset at the hot corner and had searched for someone to hit behind David Ortiz and Manny Ramirez.

On opening day at Fenway in 2006, Mike went 4-for-4 with three doubles. For the year, he gave the Red Sox just about what they expected, posting the second-best fielding average in the majors and hitting .284 with 47 doubles and 20 homers.

The 2007 season was a different story for both Mike and the Sox. Often fearful of Big Papi and Manny, opponents opted to face Lowell with the big guys on base and he made them pay. He drove home baserunners in bunches. In April, Manny, J.D. Drew, Mike and Jason Varitek hit four consecutive home runs in a game against the Yankees. In August, he tied a game against the Devil Rays with a homer, which the Sox ended up winning 2 to 1. Lowell drove in 26 runs in September alone, to help the Sox win the division. He ended up batting .324 and leading the team with 120 RBIs.

The Cleveland Indians proved to be a troublesome opponent for the Sox in the ALCS. The Tribe won three of the first four games before the Red Sox came roaring back to win the pennant. Lowell drove in three runs in Game #1 (including the winning run) and three more in Game #2. In 27 at-bats, he picked up nine hits and eight RBIs.

In the World Series, the Colorado Rockies, went quietly, falling in four uneventful games. In Game #2, Lowell's double in the bottom of the fifth broke a 1-1 tie. In Game #3, he drove in a pair in the top of the third. And in the final Game #4 of the sweep, his seventh-inning leadoff homer proved the difference in a 4–3 victory,

Lowell had hit .333 in the ALDS, .333 in the ALCS, and .400 in the World Series, with 15 postseason RBIs. He was named the World Series MVP.

After the season, Mike said all the right things. A free agent, he proclaimed his desire to stay with the Red Sox and the team responded with a three-year deal.

In 2008, both Lowell and J.D. Drew each hit a grand-slam homer against the Royals in May. But it was an injury-filled year for Mike who played in only 113 games, with two stints on the DL and hip surgery in the off-season.

In April of 2009, he brought the Sox from behind in a game against the Yankees. His three-run home run in the seventh inning, after New York had taken a 10-9 lead in the top of the inning, put the Sox up by two, in a game they won 16-11. He was named American League Player of the Week, going 10 for 23 with 11 RBIs. But the year was physically a struggle for him. After two trips to the DL, he came back in mid-July and went 40 for 122 (.328) with seven homers and 28 RBIs, finishing the season with a .290 BA.

Just before spring training in 2010, he hurt his thumb. When he came back in May, the Sox pounded the Angels, 17-8 and Mike knocked out four hits in the slugfest. Battling injuries of the previous few years, hitting only .239, and appearing in only 73 games, Lowell announced his retirement at the end of the season. On October 2nd, the Red Sox held a “Thanks, Mike Night” at Fenway Park.

Mike Lowell set and still holds both the best single-season fielding percentage record and the best career fielding record in Red Sox franchise history for a third baseman. He was a four-time All-Star and won a Silver Slugger and a Gold Glove.

He had an outstanding career and had no trouble putting his accomplishments into perspective. His second World Series ring was a nice bookend to his first, but the greatest victory of his life was his comeback against cancer.